Genetics and Genomics Open Access Research

Algorithms for Molecular Biology:

• Fast phylogenetic inference from typing data
• HAlign-II: efficient ultra-large multiple sequence alignment and phylogenetic tree reconstruction with distributed and parallel computing
• Biologically feasible gene trees, reconciliation maps and informative triples 

BioData Mining:

• Pairwise gene GO-based measures for biclustering of high-dimensional expression data
• RNA-sequence data normalization through in silico prediction of reference genes: the bacterial response to DNA damage as case study
• Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype

Biology of Sex Differences:

• Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation 
• X chromosome dosage and presence of SRYshape sex-specific differences in DNA methylation at an autosomal region in human cells

BMC Biology:

• Human evolution: the non-coding revolution
• Nothing in cancer makes sense except…
• On causal roles and selected effects: our genome is mostly junk

BMC Medical Genetics:

• Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome

• Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer

BMC Medical Genomics:

• A method to reduce ancestry related germline false positives in tumor only somatic variant calling

• Impacts of incorporating personal genome sequencing into graduate genomics education: a longitudinal study over three course years

Clinical Epigenetics:

• Pharmacological inhibition of EZH2 disrupts the female germline epigenome 
• Adipose tissue inflammation and VDRexpression and methylation in colorectal cancer

Epigenetics & Chromatin:

• Long noncoding RNAs coordinate functions between mitochondria and the nucleus
• DNA methylation and DNA methyltransferases
• Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

Genes and Nutrition: 

• Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge
• Obesity and microbiota: an example of an intricate relationship
• An update on vitamin B12-related gene polymorphisms and B12 status

Genome Medicine:

• Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

• Methylation patterns in serum DNA for early identification of disseminated breast cancer

• Sensitivity to sequencing depth in single-cell cancer genomics

• Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications​

Hereditas:

• Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations 
• Adaptation of human skin color in various populations

Human Genomics: 

• The genetic structure of the Belgian population
• Beyond genomics: understanding exposotypes through metabolomics

Mobile DNA:

• The case for not masking away repetitive DNA
• Genetic exchange in eukaryotes through horizontal transfer: connected by the mobilome
• The dynamic intein landscape of eukaryotes

Molecular Cytogenetics:

• A feasible diagnostic approach for the translocation carrier from the indication of products of conception
• 3C and 3C-based techniques: the powerful tools for spatial genome organization deciphering

Orphanet Journal of Rare Diseases:

• Prevalence, incidence and carrier frequency of 5q–linked spinal muscular atrophy – a literature review 
• KBG syndrome
• The importance of genotype-phenotype correlation in the clinical management of Marfan syndrome​​​​​​​​​​​​​​​​​​​​​